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Vaping has gained popularity as an alternative to smoking, but can vaping cause a prolonged sore throat? Prolonged and excessive vaping can potentially lead to a persistent sore throat. The chemicals in e-cigarettes, along with the heat and vapor produced, can irritate and dry out the throat, causing ongoing discomfort. If you experience a prolonged sore throat from vaping, it is advisable to consult a healthcare professional for further evaluation.